References

1) Review: The prolyl oligopeptidase family. Polgár, L. CMLS. 59: 349-362. 2002.

2) Prolyl oligopeptidase: An unusual β-propeller domain regulates proteolysis. Fülöp, V., Böcskei, Z., and Polgár, L. Cell. 94: 161–170. 1998. 

3) Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding. Szeltner, Z., et. al.  J. Mol. Biol. 340: 627-637. 2004.

4) Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. Kaszuba, K. et al. Biochimie 94: 1398-1411. 2012.

5) The  loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity. Szeltner, Z. et. al. Biochim. Biophys. Acta. 2012. http://dx.doi.org/10.1016/jj.bbapap.2012.08.012 

6) Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation. Aertgeerts, K., et. al. Protein Sci. 13: 412-421. 2004.

7) Structure and catalysis of acylamino peptidase: closed and open subunits of a dimer oligopeptidase. Harmat, V., et. al. J. Biol. Chem. 286: 1987-1998. 2011.

8) Induced-fit mechanism for prolyl endopeptidase. Li, M., Chen, C., Davies, D. R., and Chiu, T. K. J. Biol. Chem. 285: 21487-21495. 2010.

9) Catalysis of serine oligopeptidases is controlled by a gating filter mechanism. Fülöp V., Szeltner Z. and Polgár L. EMBO Rep. 1: 277-281. 2000.

10) Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Szeltner, Z. et. al. J. Biol. Chem. 277: 42613-42622. 2002.

11) Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase. Szeltner, Z., et. al. J. Biol. Chem. 277 (47): 44597-44605. 2002.

12) An overview of serine proteases. Hedstrom, L. In J. E. Coligan, B. M. Dunn, D. W. Speicher, and P. T. Wingfield (Eds.), Current Protocols in Protein Science. Wiley-Liss, Inc. 2002.

13) The catalytic triad of serine peptidases. Polgar, L.  Cell Mol Life Sci. 62: 2161-2172. 2005.

14) Mechanisms of enzyme action. Garrett, R. H. and Grisham, C. M. In P. McGahey and E. Woods (Eds.), Biochemistry (5th ed).. Canada: Brooks/Cole, Cengage Learning. 2013.

15) Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide. Racys, D. T., et. al. Bioorg. Med. Chem. 18: 4775-4782. 2010.

16) Protein identification and analysis tools on the ExPASy server. Gasteiger, E. et. al. In J. M. Walker (Ed.) The proteomics protocols handbook. Totowa, New Jersey: Humana Press Inc. 2005.

17) Dali server: conservation mapping in 3D. Nucl. Acids Res. 38, W545-549. Holm L, Rosenström, P. 2010.

18) Oligopeptidase B: A new type of serine peptidase with a unique substrate-dependent temperature sensitivity. Polgár, L.  Biochemistry. 38: 15548-15555. 1999.

19) Crystal structure of Leishmania major oligopepdiase b gives insight into the enzymatic properties of a trypanosomatid virulence factor. McLuskey, K., Paterson, N. G., Bland, N. D., Isaacs, N. W., and Mottram, J. C. J. Biol. Chem, 285 (50): 39249-29259. 2010.