Figure 1: Cholesterol synthesis pathway. (Huff MW, Telford DE. Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear. Trends Pharmacol Sci. 2005 Jul;26(7):335-40.)
Figure 2: Ribbon diagram of human OSC. (Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. Nat. 2004 Nov. 432, 118-122)
Figure 3: Cyclization of 2,3-monoepoxysqualene to lanosterol. (Huff MW, Telford DE. Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear. Trends Pharmacol Sci2005 Jul;26(7):335-40.)
