• HGPRTase
• References
• Slides

References

1)             Balendiran, G. K., Molina, J. A., Xu, Y., Torres-Martinez, J., Stevens, R., Focia, P. J., Eakin, A. E., Sacchettini, J. C. and Craig, S. P. (1999), Ternary complex structure of human hgprtase, prpp, mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding. Protein Science, 8: 1023–1031. doi: 10.1110/ps.8.5.1023

2)            Dali server: conservation mapping in 3D. Holm Liisa ; Rosenstrom Paivi. NUCLEIC ACIDS RESEARCH  Volume: 38   Supplement: 2   Pages: W545-W549   

3)              Dianne T. Keough, Ian M. Brereton, John de Jersey, Luke W. Guddat, The Crystal Structure of Free Human Hypoxanthine-guanine Phosphoribosyltransferase Reveals Extensive Conformational Plasticity Throughout the Catalytic Cycle, Journal of Molecular Biology, Volume 351, Issue 1, 5 August 2005, Pages 170-181, ISSN 0022-2836, 10.1016/j.jmb.2005.05.061.

(http://www.sciencedirect.com/science/article/pii/S0022283605006169)

4)            Garrett, R.H., Grisham, C.M. Biochemistry. (4 ed.). Boston, MA: Crooks/Cole. (2010).

5)            Holm L, Rosenström P (2010) Dali server: conservation mapping in 3D. Nucl. Acids Res. 38, W545-549

6)            Janina C. Eads, Giovanna Scapin, Yiming Xu, Charles Grubmeyer, James C. Sacchettini, The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP, Cell, Volume 78, Issue 2, 29 July 1994, Pages 325-334, ISSN 0092-8674, 10.1016/0092-8674(94)90301-8. (http://www.sciencedirect.com/science/article/pii/0092867494903018)

7)            Jayalakshmi Raman, K. Sumathy, Ranjith P. Anand, Hemalatha Balaram, A non-active site mutation in human hypoxanthine guanine phosphoribosyltransferase expands substrate specificity, Archives of Biochemistry and Biophysics, Volume 427, Issue 1, 1 July 2004, Pages 116-122, ISSN 0003-9861, 10.1016/j.abb.2004.04.014.

8)            Torres RJ, Puig JG. Hypoxanthine-guanine phosphoribosyltransferase deficiency: Lesch-Nyhan syndrome. Orphanet J Rare Dis. 2007;2:48. doi: 10.1186/1750-1172-2-48.

9)             Welin, M., Egeblad, L., Johansson, A., Stenmark, P., Wang, L., Flodin, S., Nyman, T., Trésaugues, L., Kotenyova, T., Johansson, I., Eriksson, S., Eklund, H. and Nordlund, P. (2010), Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1. FEBS Journal, 277: 4920–4930. doi: 10.1111/j.1742-4658.2010.07897.x

10)            Yiming Xu,Janina Eads,James C. Sacchettini, Charles Grubmeyer. Kinetic Mechanism of Human Hypoxanthine−Guanine Phosphoribosyltransferase: Rapid Phosphoribosyl Transfer Chemistry. Biochemistry 1997 36 (12), 3700-3712