References

      1) Maier R., Leibundgut M., and Ban N., 2008. The crystal structure of a mammalian fatty acid synthase. Science 321: 1315-1322.

      2) Kuhajda, F. P. et al., 1994. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc. Natl. Acad. Sci. U.S.A. 91: 6379-83.

      3) Kuhajada, F. P. 2006. Fatty Acid Synthase and Cancer: New Application of an Old Pathway. Cancer Res. 66: 5977-5980.

      4) Menendez, J. A., and Lupu, R. 2007. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nature Reviews Cancer. 7: 763-777.

      5) Protein identification and analysis tools on the ExPASy server. Gasteiger, E. et. al. In J. M. Walker (Ed.) The proteomics protocols handbook. Totowa, New Jersey: Humana Press Inc. 2005.

      6) Martin, J. L., and McMillan, F. M. 2002. SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold. Current Opinion in Structural Biology. 12: 783-793.

      7) Smith, S., and Tsai, S. 2007. The type I fatty acid and polyketide synthases: a tale of two megasynthases. Nat Prod Rep. 24: 1041–1072.

      8) Joshi, A. K., Witkowoski, A., and Smith, S. 1997. Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro. Biochemistry. 36:2316-22.

      9) Protein BLAST. http://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Web&PAGE=Proteins&PROGRAM=blastp&RUN_PSIBLAST=on

      10) Dali server: conservation mapping in 3D. Nucl. Acids Res. 38, W545-549. Holm L, Rosenström, P. 2010

      11) Chakravarty, B., et al. 2004. Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. Proc. Natl. Acad. Sci. U.S.A. 101: 15567-15572.

      12) Pazirandeh, M., et al. 1989. Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli. J. Biol. Chem. 264: 18195–18201.