References

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2) Xiong, Y., et al., 2012. Discovery of a Novel Glucagon Receptor Antagonist N-[(4-{(1S)-1-[3(3, 5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the Treatment of Type II Diabetes. Journal of Medicinal Chemistry 55: 6137-6148.

3) Jazayeri, A., et al. 2016. Extra-helical binding site of a glucagon receptor antagonist. Nature 533: 274-277.

4) Protein Data Bank. http://www.rcsb.org/pdb/home/home.do.

5) Protein identification and analysis tools on the ExPASy server. Gasteiger, E. et. al. In J. M. Walker (Ed.) The proteomics protocols handbook. Totowa, New Jersey: Humana Press Inc. 2005.

6) Bagger, J., et al., 2011. Glucagon antagonism as a potential therapeutic target in type 2 diabetes. Diabetes, Obesity, and Metabolism 13: 965-971.

7) Fai, Y., et al., 2013. Structure of the human glucagon class B G-protein-coupled receptor. Nature 499: 444-449.

8) Mathew, E., et al., 2013. Functional fusions of T4 lysozyme in the third intracellular loop of a G protein-coupled receptor identified by a random screening approach in yeast. Protein Engineering, Design & Selection 26: 59-71.

9) Blaber, M., et al., 1995. Alanine Scanning Mutagenesis of the a-Helix 115-123 of Phage T4 Lysozyme: Effects on Structure, Stability and the Binding of Solvent. Journal of Molecular Biology 246: 317-330.

10) Mathews, B., and Remington, J., 1974. The Three Dimensional Structure of the Lysozyme from Bacteriophage T4. Proceedings of the National Academy of Sciences of the United States 71: 4178-4182

11) Basic Local Alignment Search Tool. National Center for Biotechnology Information. 2012. http://www.ncbi.nlm.nih.gov/blast/Blast.cgi

12) Dali server: conservation mapping in 3D. Nucl. Acids Res. 38, W545-549. Holm L, Rosenström, P. 2010.