• Tyrosine Phosphatase SHP2
• References
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• Protein Monogram
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Rotation
Polarity
Secondary Structure
Subunit Structure
Three Functionally Distinct Domains
Salt Bridge
Hydrogen Bonds Stabilizing the Auto-Inhibited Conformation
Phosphopeptide Binding Sites
Phoshphopetide Binding Site with WPD Loop
D'E Loop
D'E Loop Interactions with PTP Domain's Active Site
Arg-32
PTP Signature Motif
WPD Loop
Arg-465
Cys-459
Tyrosing Phosphatase SHP-2 Superimposed onto Tyrosine Phosphatase SHP-1
Side by Side Comparison of SHP-2 and SHP-1
SHP099 Bound to Tyrosine Phosphatase SHP-2 superimposed with Tyrosine Phosphatase SHP-1
Highlighting Arg- 109 in SHP-1 and Arg-111 in SHP-2 To Depict the Binding Specificity of SHP099
Binding Pocket for SHP099
Important Residues in the Binding Pocket for SH099
Hydrogen Bonds and Hydrophobic Interactions with SHP099